Related Experiment Video
Updated: Jun 5, 2026

Highly Sensitive and Rapid Fluorescence Detection with a Portable FRET Analyzer
Published on: October 1, 2016
Specific detection of D-glucose by a tetraphenylethene-based fluorescent sensor
Yi Liu1, Chunmei Deng, Li Tang
1Institute of Biomedical Macromolecules, Department of Polymer Science and Engineering, MoE Key Laboratory of Macromolecule Synthesis and Functionalization, Zhejiang University, Hangzhou 310027, China.
Abstract:
A conceptually new "light-up" biosensor with a high specificity for d-glucose (Glu) in aqueous media has been developed. The emission from a tetraphenylethene (TPE)-cored diboronic acid (1) was greatly boosted when the fluorogen was oligomerized with Glu because of restriction of the intramolecular rotations of the aryl rotors of TPE by formation of the oligomer. Little change in the light emission was observed when 1 was mixed with D-fructose, D-galactose, or D-mannose, as these saccharides are unable to oligomerize with the fluorogen.

