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Immunomodulation with bacterial extracts in respiratory diseases
A G Palma-Carlos1, M L Palma-Carlos
1Center of Hematology and Immunology (INIC), Faculty of Medicine, Lisbon, Portugal.
Lung
|January 1, 1990
Summary
Broncho-Vaxom, an oral bacterial extract, enhances both specific and nonspecific immune responses. It activates macrophages and modulates immunoglobulin levels, boosting the body's defenses.
Area of Science:
- Immunology
- Microbiology
Background:
- Broncho-Vaxom is a lyophilized bacterial extract administered orally.
- It is known to modulate immune responses.
Purpose of the Study:
- To investigate the immunomodulatory effects of Broncho-Vaxom.
- To understand its impact on systemic and local immunity.
Main Methods:
- Oral administration of the bacterial extract in various models.
- Assessment of immune cell activation and function.
Main Results:
- Oral administration induced specific and nonspecific immune responses.
- Stimulated systemic and local immune responses.
- Activated macrophages and modulated immunoglobulin levels.
- Potentiated lymphocyte response to phytohemagglutinin (PHA) and mitogens.
Conclusions:
- Broncho-Vaxom effectively stimulates the immune system.
- It enhances macrophage activity and immunoglobulin modulation.
- Further research is ongoing regarding its effect on T-lymphocyte subpopulations.