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Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...

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Related Experiment Video

Updated: Jun 5, 2026

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
09:03

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management

Published on: March 28, 2025

Neuropathic pain: mind-body considerations.

Brian Hainline1

  • 1Department of Neurology, New York University School of Medicine, NY, USA. bhainline@prohealthcare.com

Neurologic Clinics
|December 22, 2010
PubMed
Summary

Neuroscience research reveals that thoughts, originating in the brain, influence its function and impact the body. This mind-body connection is crucial for understanding neuropathic pain, a complex neuropsychiatric condition.

Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Emerging research explores the intricate connection between the mind and body.
  • Understanding the brain's role in thought and its influence on physiological processes is advancing.
  • The bidirectional relationship between mental states and physical health is a key area of study.

Purpose of the Study:

  • To highlight the brain-based nature of thought and its impact on neural function.
  • To establish the continuum and bidirectionality between mind and body, thought and brain, and emotions and physiology.
  • To provide a foundational understanding for the complex neuropsychiatric condition of neuropathic pain.

Main Methods:

  • Review of current neuroscience and psychiatric research.
  • Conceptual analysis of mind-body interactions.

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Last Updated: Jun 5, 2026

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
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Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy
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Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

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  • Exploration of the neurobiological underpinnings of thought and emotion.

    • Main Results:

    • Thought is fundamentally brain-based and actively modulates brain function.
    • A continuous and bidirectional interplay exists between mental states (mind, thought, emotions) and physiological processes.
    • This interplay is integral to the manifestation and understanding of neuropathic pain.

    Conclusions:

    • The mind-body continuum is a critical framework for understanding neuropsychiatric conditions.
    • Neuropathic pain, a neuropsychiatric disorder, is better understood through the lens of integrated brain-body interactions.
    • Future research should continue to explore these bidirectional pathways to improve patient outcomes.