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Related Experiment Video

Updated: Jun 5, 2026

Imaging Centrosomes in Fly Testes

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

Centrosome biogenesis: centrosomin sizes things up!

Mariana Gomez-Ferreria¹, Laurence Pelletier

¹Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada.

Current Biology : CB

|December 22, 2010

Summary

Centrosomes, crucial for cell division, involve a link between centrioles and pericentriolar material. This connection influences and regulates overall centrosome size.

Area of Science:

Cell Biology
Molecular Biology
Cytoskeleton Dynamics

Background:

Centrosomes are vital organelles organizing microtubules.
They consist of a centriole pair and surrounding pericentriolar material (PCM).
The PCM houses protein complexes essential for microtubule nucleation.

Purpose of the Study:

To investigate the relationship between centrioles and PCM.
To understand how this interaction affects centrosome size regulation.

Main Methods:

Utilized advanced microscopy techniques.
Employed biochemical assays to analyze protein composition.
Performed genetic manipulation to study centriole-PCM interactions.

Main Results:

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Related Experiment Videos

Last Updated: Jun 5, 2026

Imaging Centrosomes in Fly Testes

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Published on: September 20, 2013

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

Published on: August 13, 2016

Identified a direct functional link between centrioles and PCM.
Demonstrated that this link actively modulates centrosome size.
Observed specific protein complexes mediating this interaction.

Conclusions:

Centriole-PCM interactions are key regulators of centrosome dimensions.
This finding offers new insights into centrosome biology and its role in cell division.