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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
CD23 expression in follicular lymphoma: clinicopathologic correlations
Horatiu Olteanu1, Timothy S Fenske, Alexandra M Harrington
1Dept of Pathology, Medical College of Wisconsin, Milwaukee, 53226, USA.
American Journal of Clinical Pathology
|December 22, 2010
Summary
CD23 expression in follicular lymphoma (FL) is associated with better survival outcomes. While higher-grade FL and non-inguinal lymph node sites show less CD23 positivity, CD23+ FL patients experience significantly longer event-free and overall survival.
Area of Science:
- Hematology
- Oncology
- Immunopathology
Background:
- Follicular lymphoma (FL) is a common B-cell malignancy characterized by specific immunophenotypic markers.
- The role of CD23 expression in FL's clinical behavior and prognosis remains incompletely understood.
- Existing research indicates variable CD23 expression in FL, necessitating further investigation into its significance.
Purpose of the Study:
- To investigate the prevalence of CD23 expression in follicular lymphoma.
- To correlate CD23 expression with clinicopathologic features, including FL grade and lymph node location.
- To determine the prognostic value of CD23 expression in follicular lymphoma patients.
Main Methods:
- Flow cytometry analysis of CD23 expression in 69 follicular lymphoma lymph node samples.
- Correlation of CD23 status with tumor grade (1, 2, and 3) and lymph node site (inguinal vs. others).
- Statistical analysis to assess the relationship between CD23 expression and patient survival outcomes (overall and event-free survival).
Main Results:
- CD23 expression was detected in 70% (48/69) of follicular lymphoma cases.
- Grade 3 FL showed significantly lower CD23 positivity (25%) compared to grades 1 and 2 (83%; P < .001).
- FLs originating in inguinal lymph nodes exhibited higher CD23 expression (87%) than those from other sites (61%; P = .029).
- Patients with CD23+ FL demonstrated significantly longer overall survival (P = .002) and event-free survival (P < .0001) compared to CD23- cases.
Conclusions:
- Grade 3 follicular lymphoma is less likely to express CD23 than lower grades.
- CD23 expression is more frequent in follicular lymphoma arising in inguinal lymph nodes.
- CD23 positivity is a favorable prognostic marker in follicular lymphoma, indicating improved patient survival.
