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Related Experiment Video

Updated: Jun 5, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Post-stroke infection: a role for IL-1ra?

Pat Tanzi¹, Kevin Cain, Angela Kalil

¹Department of Neurology, University of Washington, School of Medicine, Harborview Medical Center, Box 359775, 325 9th Ave, Seattle, WA 98104-2499, USA.

Neurocritical Care

|December 22, 2010

Summary

Post-stroke infections are common and linked to poor outcomes. This study found Interleukin-1 receptor antagonist (IL-1ra) is independently associated with increased infection risk after stroke.

Related Experiment Videos

Last Updated: Jun 5, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Area of Science:

Neuroscience
Immunology
Clinical Medicine

Background:

Infection post-stroke is a significant complication, worsening patient outcomes.
Stroke-induced immunologic dysfunction may increase infection susceptibility.
The role of cytokines and hormones in post-stroke infection risk requires further investigation.

Purpose of the Study:

To investigate the association between immunomodulatory cytokines, hormones, lymphocyte function, and infection risk in stroke patients.
To explore the independent contribution of these factors to post-stroke infections.

Main Methods:

112 ischemic stroke patients were enrolled shortly after stroke onset.
Blood samples were analyzed for cortisol, IL-10, IL-1ra, and lymphocyte counts/function at 72 hours post-stroke.
Infections were monitored up to 21 days post-stroke.

Main Results:

Infection occurred in 25% of patients, with stroke severity being the primary predictor.
Elevated plasma cortisol, IL-10, IL-1ra, and reduced lymphocyte numbers correlated with infection risk.
After adjusting for stroke severity, only IL-1ra remained independently associated with infection risk.

Conclusions:

Increased plasma IL-1ra levels are independently linked to a higher risk of infection following stroke.
This finding suggests IL-1ra may serve as a potential biomarker for post-stroke infection.
Further research is warranted to confirm these implications for future stroke therapies.