Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The synapsins and the regulation of synaptic function.

M Bähler1, F Benfenati, F Valtorta

  • 1Laboratory of Molecular and Cellular Neuroscience, Rockfeller University, New York, NY 10021.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Graphene oxide increases the phototransduction efficiency of copolymeric nanoimplants and rescues visual functions in rat and pig models of Retinitis pigmentosa.

Nature communications·2025
Same author

Spiropyran-based glutamate nanovalve for neuronal stimulation.

Materials horizons·2025
Same author

Solid-State Nanopores for Spatially Resolved Chemical Neuromodulation.

Nano letters·2024
Same author

Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats.

Nature communications·2022
Same author

[Flexible assertive community treatment (FACT) as part of a community (health) network].

Tijdschrift voor psychiatrie·2020
Same author

Organic semiconductors for artificial vision.

Journal of materials chemistry. B·2020

Synapsins I and II are phosphoproteins regulating neurotransmitter release by linking synaptic vesicles to actin filaments. Their interactions are modulated by phosphorylation, suggesting shared functions between synapsin I and II.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Synapsins I and II are key phosphoproteins in synaptic vesicle regulation.
  • They play a crucial role in the short-term control of neurotransmitter release.

Purpose of the Study:

  • To present a working model for the molecular mechanisms of synapsin action.
  • To elucidate the role of synapsins in synaptic vesicle-actin filament interactions.

Main Methods:

  • Review of existing literature on synapsin function.
  • Analysis of molecular mechanisms involving phosphorylation and signal transduction pathways.

Main Results:

  • Synapsin I is proposed to link synaptic vesicles to presynaptic actin filaments.

Related Experiment Videos

  • Phosphorylation reversibly modulates these synapsin I interactions via signal transduction pathways.

    • Conclusions:

    • The proposed model highlights the dynamic regulation of synaptic vesicle trafficking by synapsins.
    • High homology suggests synapsin II shares functional properties with synapsin I, implicating both in neurotransmission regulation.