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Published on: July 31, 2017
[Protective effect of magnesium on hippocampal neurons damage induced by glutamic acid]
1School of life sciences, Xiangtan Normal University of Hunan, Xiangtan 411201, China.
Aim:
To investigate the effect of magnesium ion (Mg2+) on neuronic damage induced by 0.1 mmol/L glutamic acid.
Methods:
The neurons isolated from hippocampus in rats were cultured for 6-9 days, and then randomly divided into three groups: A. medium alone. B. medium + glutamic acid. C. medium+ Mg2+, and + glutamic acid (30 min late).
Results:
(1) DAs compared with A group, the survival rate of hippocampal neurons in B group was remarkably decreased in dose dependent mauner. (2) In contrast to B group, when the concentration of Mg2+ was lower, the survival rates of hippocampal neurons in C group was significantly increased.
Conclusion:
Mg2+ in lower concentration could protect hippocampal neurons from damage induced by glutamic acid.
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