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Change in alpha-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH
V I Bunik1, O A Buneeva, V S Gomazkova
1Department of Biochemistry, Moscow State University, USSR.
FEBS Letters
|August 20, 1990
Abstract:
Reducing 2 SH-groups of KGD by dihydrolipoate leads to cooperativity in substrate binding. Cooperative properties of KGD in the KGD complex are modulated by NADH. Physiological significance of these observations is discussed.