Related Experiment Video
Updated: Jun 5, 2026
12:26
Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Cell cyclins: triggering elements of cancer or not?
Michael Stamatakos1, Victoria Palla, Ioannis Karaiskos
14th Department of Surgery, Medical School, University of Athens, Attikon General Hospital, Athens, Greece. mixalislak@gmail.com
World Journal of Surgical Oncology
|December 24, 2010
Summary
Cyclins, crucial for cell cycle progression, can drive cancer when their function is disrupted. This review highlights how G1/S cyclins, particularly cyclin D and E, contribute to tumor formation and offer potential therapeutic targets.
Area of Science:
- Cell Biology
- Oncology
- Molecular Biology
Background:
- Cyclins are essential regulators of the cell cycle.
- Dysfunctional cyclins are implicated in cancer development.
- Emerging evidence points to novel oncogenic roles for cyclins.
Purpose of the Study:
- To review the aberrant expression of G1/S cyclins, specifically cyclin D and cyclin E.
- To elucidate the pathways through which these cyclins promote tumor formation.
- To examine the involvement of cyclin D and E in various cancer types.
Main Methods:
- Literature review of recent studies on cyclin function and cancer.
- Analysis of pathways linking G1/S cyclins to oncogenesis.
- Compilation of data on cyclin D and E involvement across different malignancies.
Main Results:
- Aberrant expression of cyclin D and cyclin E is a common feature in many cancers.
- These cyclins contribute to uncontrolled cell proliferation and tumor growth through specific molecular pathways.
- Cyclin D and E play significant roles in the pathogenesis of diverse cancer types.
Conclusions:
- The oncogenic potential of G1/S cyclins, especially cyclin D and E, is well-established.
- Understanding these mechanisms provides a basis for developing targeted cancer therapies.
- Targeting cyclin D and E pathways represents a promising strategy for cancer treatment.
Related Concept Videos
02:39Positive Regulator Molecules
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
01:45Positive Regulator Molecules
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
02:38Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
02:38Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
02:15M-Cdk Drives Transition Into Mitosis
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
02:15M-Cdk Drives Transition Into Mitosis
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...