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Updated: Jun 5, 2026
09:01
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
[Leukemia stem/progenitor cells and target therapy for leukemia-- review]
1Department of Hematology, Southeast University Medical College, Nanjing 210009, Jiangsu Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|December 24, 2010
Summary
Human leukemias originate from leukemia stem/progenitor cells (LSPC). Targeting LSPC offers new strategies to overcome drug resistance and relapse in leukemia treatment.
Area of Science:
- Hematology
- Cancer Biology
- Stem Cell Research
Context:
- Leukemia is a clonal malignancy originating from hematopoietic stem/progenitor cells.
- Drug resistance and relapse are significant challenges in leukemia treatment.
- Leukemia stem/progenitor cells (LSPC) are implicated in leukemia pathogenesis.
Purpose:
- To review the molecular characteristics of LSPC.
- To summarize advances in targeted therapies against LSPC.
Summary:
- This review covers the molecular features of LSPC.
- It discusses therapeutic strategies targeting LSPC, including surface molecule targeting and modulating the LSPC-microenvironment interaction.
- Regulation mechanisms of specific molecules involved in LSPC function are also examined.
Impact:
- Understanding LSPC is crucial for developing novel leukemia therapies.
- Targeting LSPC may overcome treatment resistance and prevent relapse.
- This research provides insights into LSPC biology and therapeutic interventions.
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