Managing invasive fungal infections: relying on clinical instincts or on a rational navigation system?

Ben E de Pauw1, Claudio Viscoli

  • 1Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. be.depauw@yahoo.com

Insights

Managing invasive fungal disease in immunocompromised patients requires specialized knowledge. Integrated care pathways offer tools for rational patient management and practice improvement.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Oncology

Background:

  • Invasive fungal disease (IFD) management in immunocompromised hosts is challenging.
  • Physicians often focus on the primary disease, not infectious complications.
  • A structured approach is needed to guide IFD diagnosis and treatment.

Purpose of the Study:

  • To provide physicians with tools for managing IFD in immunocompromised patients.
  • To offer an integrated care pathway for rational patient management.
  • To facilitate early suspicion and diagnosis of IFD.

Main Methods:

  • Development of integrated care pathways for IFD management.
  • Emphasis on multidisciplinary team collaboration.
  • Establishment of minimum requirements for effective IFD care.

Main Results:

  • Integrated care pathways serve as objective instruments for practice audits.
  • Pathways help identify opportunities for practice change.
  • Standardized pathways can improve IFD management consistency.

Conclusions:

  • Integrated care pathways are valuable tools for managing IFD in immunocompromised hosts.
  • Multidisciplinary teams and agreed-upon standards are crucial for pathway success.
  • Regular audits of pathways enable continuous quality improvement in IFD care.

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).
Reason and Intuition01:37

Reason and Intuition

The human brain processes information for decision-making using one of two routes: an intuitive system and a rational system (Epstein, 1994; popularized by Kahneman, 2011 as System 1 and System 2, respectively). The intuitive system is quick, impulsive, and operates with minimal effort, relying on emotions or habits to provide cues for what to do next, while the rational system is logical, analytical, deliberate, and methodical. Research in neuropsychology suggests that the brain can only use...
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...