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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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A Bioinformatics Pipeline to Accurately and Efficiently Analyze the MicroRNA Transcriptomes in Plants
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mESAdb: microRNA expression and sequence analysis database.

Koray D Kaya1, Gökhan Karakülah, Cengiz M Yakicier

  • 1Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey.

Nucleic Acids Research
|December 24, 2010
PubMed
Summary
This summary is machine-generated.

The microRNA Expression and Sequence Analysis database (mESAdb) offers tools for analyzing microRNA sequences and expression data. It enables multivariate analysis across species, aiding in microRNA research.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) play crucial roles in gene regulation.
  • Comprehensive databases are essential for analyzing miRNA sequence and expression data.
  • Existing tools may lack integrated multivariate analysis capabilities across multiple taxa.

Purpose of the Study:

  • To present mESAdb, a regularly updated database for multivariate analysis of miRNA sequences and expression.
  • To provide a user-friendly interface coupled with powerful statistical analysis tools.
  • To facilitate the association of miRNA subsets with biological annotation databases.

Main Methods:

  • Development of a modular database with a PHP/JavaScript user interface.
  • Integration of statistical analysis and visualization packages from the R language.
  • Inclusion of mature miRNA sequences, target data, and expression datasets (human, mouse, zebrafish).

Main Results:

  • mESAdb supports mining of miRNA expression data by manual selection or motif.
  • Enables pair-wise multivariate analysis of expression data within and between taxa.
  • Facilitates association of miRNA subsets with HUGE Navigator, KEGG, and GO databases.

Conclusions:

  • mESAdb is an interactive and expandable tool for miRNA sequence and expression analysis.
  • The use of R packages allows for future additions of datasets and analysis tools.
  • User-specified data upload enhances mESAdb's utility for diverse research needs.