Related Experiment Video
Updated: Jan 25, 2026

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
Published on: September 30, 2025
Lipoprotein association studies: taking stock and moving forward
Philippa J Talmud1, Nikos Yiannakouris, Steve E Humphries
1Department of Medicine, Centre for Cardiovascular Genetics, University College London, 5 University St, London, UK. p.talmud@ucl.ac.uk
Genome-wide association studies (GWASs) have identified novel genes for lipid traits. Collaborative efforts and gene-centric approaches are advancing our understanding of lipid metabolism and potential drug targets.
Area of Science:
- Genetics
- Metabolic Diseases
- Pharmacogenomics
Background:
- Significant advancements in identifying genes linked to lipid traits have been achieved.
- Single genome-wide association studies (GWASs) may be nearing their limit for discovering novel genes.
Purpose of the Study:
- To review the progress in identifying genes associated with lipid traits.
- To explore novel pathways and potential drug targets in lipid metabolism.
Main Methods:
- Utilizing SNP arrays and imputation techniques.
- Collaborative consortia analyzing pooled GWAS data.
- Employing gene-centric approaches with specialized chips for deep gene coverage.
Main Results:
- Collaborative consortia identified 56 novel lipid-associated loci from pooled GWAS data.
- Gene-centric approaches have aided in identifying independently acting and functional variants.
- The percentage of variance explained for each trait remains around 10-12%.
Conclusions:
- GWAS-identified loci reveal new pathways in lipid metabolism, offering innovative drug targets.
- Lipid gene scores may possess clinical utility beyond single lipid measurements.
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