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Association of ADAM33 gene polymorphisms with asthma in Indian children

Shally Awasthi1, Priya Tripathi, Subramaniam Ganesh

  • 1Department of Pediatrics, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India. shallya@rediffmail.com

Journal of Human Genetics
|December 24, 2010
PubMed

Insights

Genetic variations in the ADAM33 gene are linked to childhood asthma risk in Indian children. Specific single-nucleotide polymorphisms (SNPs) and haplotypes significantly influence susceptibility to this common respiratory condition.

Area of Science:

  • Genetics
  • Pediatrics
  • Respiratory Medicine

Background:

  • Asthma is a prevalent chronic childhood respiratory disorder.
  • Asthma exacerbations contribute significantly to childhood morbidity and hospitalizations.
  • Understanding genetic factors influencing asthma susceptibility is crucial for early intervention.

Purpose of the Study:

  • To investigate the association between ADAM33 gene single-nucleotide polymorphisms (SNPs) and asthma in Indian children.
  • To identify specific SNPs and haplotypes of the ADAM33 gene that confer risk or protection against childhood asthma.
  • To analyze the genetic susceptibility to asthma in a pediatric population from India.

Main Methods:

  • A case-control study design was employed.
  • Genotyping of five ADAM33 gene SNPs (F+1, S2, ST+4, ST+5, V4) was performed using PCR-restriction fragment length polymorphism.
  • Statistical analyses included the chi-squared test, logistic regression, and haplotype analysis using the expectation-maximization algorithm.

Main Results:

  • Significant associations were found between SNPs S2 and ST+5 and asthma risk.
  • Homozygous mutant genotypes and mutant alleles of F+1, ST+4, and V4 SNPs were associated with increased asthma risk.
  • Specific haplotypes (AGCCT, GGACT, AGCCC) showed a positive association with asthma, while others (ACAGT, AGCGC, AGCGT, GCAGC, GCCGT) exhibited a protective effect.

Conclusions:

  • Polymorphisms in the ADAM33 gene are associated with susceptibility to childhood asthma in the Indian population.
  • Certain ADAM33 gene variants may modify an individual's risk of developing asthma.
  • These findings contribute to understanding the genetic basis of asthma in children.

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