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The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents
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A population-specific HTR2B stop codon predisposes to severe impulsivity.

Laura Bevilacqua1, Stéphane Doly, Jaakko Kaprio

  • 1Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, Maryland 20852, USA.

Nature
|December 24, 2010
PubMed
Summary
This summary is machine-generated.

A rare HTR2B gene variant found in Finnish individuals is linked to impulsivity and associated psychiatric conditions. This discovery highlights the role of specific genetic factors in complex behaviors.

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Area of Science:

  • Neurogenetics
  • Psychiatric Genetics

Background:

  • Impulsivity is a key feature in psychiatric disorders, suicidality, and violent behavior.
  • The genetic underpinnings of impulsivity are complex and challenging to identify.

Purpose of the Study:

  • To identify genes associated with impulsivity in a founder population.
  • To investigate the role of the serotonin and dopamine pathways in impulsivity.

Main Methods:

  • Exon-focused sequencing of individuals with impulsive traits.
  • Targeted sequencing of 14 genes in the serotonin and dopamine pathways.
  • Assessed gene expression in the human brain and molecular functionality of identified variants.

Main Results:

  • A common stop codon in the HTR2B gene, exclusive to the Finnish population, was identified.
  • This HTR2B variant was associated with impulsivity-related psychiatric diseases in population and family-based analyses.
  • Mice lacking Htr2b exhibited increased impulsive behaviors.

Conclusions:

  • The study identifies a specific HTR2B gene variant contributing to impulsivity and related psychiatric conditions.
  • Founder populations are valuable for tracing the effects of rare alleles on complex behavioral phenotypes.
  • HTR2B plays a significant role in regulating impulsive behaviors.