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Updated: Jun 5, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
[Research of regulation on calcium-activated potassium channel in hypothalamic neurons by nitric oxide]
Shuai Wang1, Zhen-Gang Wang, Xu-Dong Zhang
1Department of Neurosurgery, Bethune International Peaceful Hospital, Hebei, Shijiazhuang 050082, China.
Aim:
To study the effects of nitric oxide on calcium-activated potassium channels (KCa) in hypothalamus neurons.
Methods:
The data was recorded by adopting cell-attached or inside-out configuration of patch-clamp technique.
Results:
Nitric oxide was found to increase the open probability of the channels directly or through increasing cGMP, which resulted from both the prolongation of open period and increase of open frequency.
Conclusion:
Nitric oxide could regulate calcium-activated potassium channels in hypothalamic neurons through alternative pathways.
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