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[Effects of morphine on K+ currents in caudate nucleus of neonatal rat]
Shu-Zhuo Zhang1, Yu-Rong Li, Li-Jun Li
1Harbin Medicine University, Harbin 150086, China.
Aim:
The effects of morphine on the potassium ionic currents of caudate nucleus neurons of neonatal rat were studied.
Methods:
Using of whole cell voltage clamp technique on caudate nucleus neurons, applied morphine chronically or acutely on it. In order to research the effects of morphine for voltage-gated of potassium ionic currents.
Results:
The amplitude of potassium ionic currents are increased by applied morphine acutely in caudate nucleus from (2.6 +/- 0.4) nA to (3.3 +/- 0.5) Na, naloxone can block the effect of morphine on K+ current and the currents are decreased to (2.4 +/- 0.4) nA. If applied morphine in caudate nucleus chronically, the amplitude of potassium ionic currents are increased from (2.6 +/- 0.4) nA to (3.1 +/- 0. 5) nA. After applied naloxone, the currents are decreased to (2.4 +/- 0.4) nA.
Conclusion:
The effects of morphine increased potassium ionic currents by micro-opioid receptor mediated and induced the hyper polarization of neurons, leading to inhibition of neural activity.
