Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Effects of <i>MTHFR</i> and <i>GGH</i> gene polymorphisms on plasma concentrations and toxicity following high-dose methotrexate therapy in children with acute lymphoblastic leukemia].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsยท2025
Same author

Quadruple therapy with immunotherapy and chemotherapy as first-line conversion treatment for unresectable advanced gastric adenocarcinoma: A case report.

World journal of gastrointestinal oncologyยท2025
Same author

Roles of the tumor microenvironment in the resistance to programmed cell death protein 1 inhibitors in patients with gastric cancer.

World journal of gastrointestinal oncologyยท2024
Same author

[Clinical features of children with coronavirus disease 2019 in different age groups during the epidemic of Omicron variant].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsยท2023
Same author

[Spatial and Temporal Distribution Characteristics and the Retention Effects of Nutrients in Xiangjiaba Reservoir].

Huan jing ke xue= Huanjing kexueยท2019
Same author

[mRNA expression of MDR3 gene in the blood of preterm infants with parenteral nutrition-associated cholestasis].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsยท2019
Same journal

Engineering Ophthalmic Nanoemulsion Platforms: Design Principles and Translational Applications in Ocular Drug Delivery.

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiologyยท2026
Same journal

Multifunctional Quantum Dots: A Review of Emerging Roles in Technology and Sustainability.

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiologyยท2026
Same journal

Sunvozertinib A Next-Generation EGFR Exon 20 Insertion Inhibitor Transforming NSCLC Therapy.

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiologyยท2026
Same journal

Electromagnetic Modulation of Biological Systems: Emerging Perspectives in Bioelectronic Healing.

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiologyยท2026
Same journal

In Silico Approaches in Benzimidazole Derivatives Research: Recent Insights.

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiologyยท2026
Same journal

2-Aminobenzothiazole: A Privileged Scaffold for Tyrosine Kinase-Targeted Anticancer Agents.

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiologyยท2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
06:58

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement

Published on: June 25, 2016

[Modulation with bupleurum root on brain electrical activities in epileptic model].

Shu-Mei Xu1, Kai-Jun Zheng, Jin-Yan He

  • 1Department of Physiology, Tianjin Medical University, Tianjin 300070, China.

Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology
|December 25, 2010
PubMed
Summary
This summary is machine-generated.

Bupleurum root significantly reduced seizure duration and prolonged seizure intervals in epilepsy models. This traditional Chinese medicine demonstrates a distinct antiepileptic effect by inhibiting brain electrical activity.

More Related Videos

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
06:58

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement

Published on: June 25, 2016

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

Area of Science:

  • Pharmacology
  • Neuroscience
  • Traditional Chinese Medicine

Context:

  • Epilepsy is a chronic neurological disorder characterized by recurrent seizures.
  • Current antiepileptic drugs have limitations and side effects.
  • Investigating natural compounds for novel therapeutic strategies is crucial.

Purpose:

  • To investigate the antiepileptic effects of Bupleurum root.
  • To evaluate the impact of Bupleurum root on electroencephalogram (EEG) and hippocampal activity in epilepsy models.

Summary:

  • Bupleurum root administration significantly shortened seizure time and duration while prolonging seizure intervals in pilocarpine-induced epilepsy models in rabbits and rats (P < 0.05).
  • Extracellular recordings showed that Bupleurum root reduced the amplitude of evoked field potentials in epileptic hippocampal slices by 20.41% and restored activity within 6.86 minutes (P < 0.001).

Impact:

  • Bupleurum root demonstrates a notable inhibitory effect on brain electrical activity in epilepsy models.
  • Findings suggest Bupleurum root possesses distinct antiepileptic properties, warranting further research for clinical application.