[Experimental studies on antiarrhythmic effect of jumi extraction]
1Department of Physiology, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Aim:
To investigate the antiarrhythmic effect of jumi (JM) extraction.
Methods:
The conventional antiarrhythmic methods were used.
Results:
Administration of JM extraction reduced the occurrence of ventricular fibrillation induced by chloroform in a dose-dependent manner in mice. Quinidine significantly decreased the number of ventricular premature beats and ventricular tachycardia, shortened the duration of arrhythmia in aconitine-treated rats. But JM extraction had no effect on aconitine-induced arrhythmia. Compared with control, arrhythmia score was lower in ischemia/reperfusion rats which pretreated with 2.0 g/kg of JM extraction.
Conclusion:
JM extraction has obvious protection effects in chloroform- and ischemia-induced arrhythmia, but has no effect in aconitine-induced arrhythmia.
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