Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Physical therapy in patients with Parkinson's disease treated with Deep Brain Stimulation: a Delphi panel study.

medRxiv : the preprint server for health sciences·2024

Same author

Adaptive Deep Brain Stimulation in Parkinson's Disease: A Delphi Consensus Study.

medRxiv : the preprint server for health sciences·2024

Same author

Clinical assessment of upper limb hypertonia in central neurological diseases.

Hand surgery & rehabilitation·2021

Same author

Chronic skin disease and levels of physical activity in 17 777 Spanish adults: a cross-sectional study.

Clinical and experimental dermatology·2020

Same author

Programming parameters of subthalamic deep brain stimulators in Parkinson's disease from a controlled trial.

Parkinsonism & related disorders·2019

Same author

Adverse events associated with deep brain stimulation in patients with childhood-onset dystonia.

Brain stimulation·2019

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Deep brain stimulation in Parkinson's disease.

S J Groiss¹, L Wojtecki, M Südmeyer

¹Department of Neurology, Center for Movement Disorders and Neuromodulation, Heinrich-Heine-University of Düsseldorf, Germany, Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine-University of Düsseldorf, Germany.

Therapeutic Advances in Neurological Disorders

|December 25, 2010

Summary

Deep brain stimulation (DBS) is effective for advanced Parkinson's disease (PD), significantly improving motor symptoms and quality of life. Research is exploring earlier DBS intervention to enhance long-term patient well-being.

Keywords:

DBS GPi Parkinson's disease STN VIM deep brain stimulation subthalamic nucleus

More Related Videos

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Area of Science:

Neurosurgery
Neurology
Movement Disorders

Background:

Deep brain stimulation (DBS) has emerged as a key therapy for advanced Parkinson's disease (PD) over the past 15 years.
Effective management necessitates a multidisciplinary team, including neurologists and neurosurgeons specializing in movement disorders.

Purpose of the Study:

To evaluate the efficacy of subthalamic nucleus (STN) DBS for medically refractory Parkinson's disease motor complications.
To assess the impact of STN-DBS on quality of life and medication requirements compared to optimal medical management.

Main Methods:

High-frequency DBS targeting the subthalamic nucleus (STN) for patients with advanced PD.
Assessment of motor symptoms, dyskinesias, medication needs, and quality of life.

Main Results:

STN-DBS significantly reduces dyskinesias and dopaminergic medication needs in Parkinson's disease patients.
Subthalamic nucleus DBS leads to sustained improvement in cardinal motor symptoms and enhanced quality of life compared to medical treatment.
Potential risks include surgery-related adverse events and device-related complications.

Conclusions:

Subthalamic nucleus DBS is a highly effective treatment for advanced Parkinson's disease, offering significant motor and quality of life benefits.
The current average of 13 years of disease duration before DBS initiation is being re-evaluated, with ongoing research into earlier intervention.
Investigating earlier DBS implantation aims to prevent psychosocial decline and prolong quality of life in Parkinson's disease patients.