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Updated: Jun 5, 2026

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Primary CNS lymphoma.

¹Knappschaftskrankenhaus, Bochum-Langendreer, Ruhr-University Bochum, Germany uwe.schlegel@kk-bochum.de.

Therapeutic Advances in Neurological Disorders

|December 25, 2010

Summary

This summary is machine-generated.

Primary CNS Lymphoma (PCNSL) is a rare brain tumor. Treatment strategies vary by age, focusing on high-dose methotrexate chemotherapy for younger patients and MTX combinations for older adults, while avoiding radiotherapy due to neurotoxicity risks.

Keywords:

CNS lymphoma brain tumors methotrexate non-Hodgkin's lymphoma temozolomide

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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Area of Science:

Neuro-oncology
Hematology
Medical imaging

Background:

Primary CNS Lymphoma (PCNSL) constitutes 3% of primary brain tumors, typically affecting individuals around 62 years old.
PCNSL often presents as enhancing lesions near ventricles on MRI, diagnosed via stereotactic biopsy confirming high-grade non-Hodgkin's B-cell lymphoma.

Purpose of the Study:

To summarize current understanding and therapeutic approaches for Primary CNS Lymphoma.
To outline treatment recommendations based on patient age and disease status.

Main Methods:

Review of diagnostic procedures, including stereotactic biopsy and MRI findings.
Analysis of therapeutic strategies, including chemotherapy regimens and the role of radiotherapy.
Consideration of treatment approaches for different age groups and disease stages (initial, relapse, refractory).

Main Results:

High-dose methotrexate (MTX)-based polychemotherapy or autologous stem cell rescue are options for younger, eligible patients aiming for cure.
For patients over 60, MTX-based chemotherapy, potentially with temozolomide, is recommended due to lack of established curative regimens with acceptable toxicity.
Radiotherapy as initial treatment is not recommended outside clinical trials due to severe long-term neurotoxicity risks when combined with MTX-based chemotherapy.

Conclusions:

Treatment for PCNSL should be tailored to patient age, with curative intent for younger individuals and manageable toxicity for older patients.
Salvage therapy is beneficial for patients with relapsed or refractory disease, with choices dependent on prior treatments.
Clinical trial participation is encouraged for eligible patients to advance evidence-based treatment strategies.