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Related Experiment Video

Updated: Jun 5, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Evaluating an experimental dentifrice containing chloramine-T: a preliminary study.

Camila Tirapelli1, Flávio Landi, José Paulo Ribas

  • 1Department of Dental Materials and Prosthesis, University of Sao Paulo, Brazil. catirapelli@forp.usp.br

Oral Health & Preventive Dentistry
|December 25, 2010
PubMed
Summary

An experimental dentifrice with chloramine-T (CH) and a triclosan (TR) toothpaste showed similar effectiveness in reducing plaque and gingival bleeding. Both oral hygiene products significantly improved key dental health indicators after seven days of use.

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Area of Science:

  • Oral Health
  • Periodontology
  • Antimicrobial Agents

Background:

  • Dental plaque and sulcus bleeding are indicators of oral health status.
  • Antimicrobial agents in dentifrices aim to reduce these indicators.
  • Chloramine-T is an antimicrobial agent with potential oral health applications.

Purpose of the Study:

  • To evaluate the clinical efficacy of an experimental dentifrice containing 1% chloramine-T (CH).
  • To compare the efficacy of the CH dentifrice against a commercial triclosan (TR) dentifrice.

Main Methods:

  • A 7-day, double-blind, randomized comparative study was conducted on 30 patients.
  • Plaque Index (PI) and Sulcus Bleeding Index (SBI) were assessed at baseline and after 7 days.
  • Patients used either the CH or TR dentifrice three times daily.

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Main Results:

  • Both CH and TR dentifrices significantly reduced PI scores.
  • Both CH and TR dentifrices significantly decreased SBI values.
  • No statistically significant difference was observed between the CH and TR dentifrices for PI and SBI.

Conclusions:

  • The experimental chloramine-T dentifrice (CH) demonstrated comparable efficacy to the commercial triclosan dentifrice (TR).
  • Both dentifrices effectively reduced plaque and gingival bleeding.
  • CH dentifrice shows potential as an effective agent for improving oral health indices.