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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Amyloid Fibrils

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Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
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Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[Cutaneous amyloidosis].

S Schreml¹, R-M Szeimies, M Landthaler

¹Klinik und Poliklinik für Dermatologie, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg. stephan.schreml@klinik.uni-regensburg.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|December 25, 2010

Summary

This summary is machine-generated.

Amyloids are protein aggregates with diverse roles, some beneficial and others causing diseases like amyloidoses. This paper reviews amyloid types, diagnostic methods, and treatments, distinguishing functional from pathogenic forms.

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Performing and Processing FNA of Anterior Fat Pad for Amyloid

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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Performing and Processing FNA of Anterior Fat Pad for Amyloid

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

Area of Science:

Biochemistry
Molecular Biology
Pathology

Context:

Amyloids, conserved protein aggregates, have dual roles: essential biological functions or disease causation.
Amyloidogenesis mechanisms are complex and under active research.
Human amyloidoses can manifest in the skin or as secondary cutaneous signs.

Purpose:

To provide a comprehensive overview of different types of amyloidoses.
To detail current diagnostic and therapeutic strategies for amyloidoses.
To differentiate between functional and disease-causing amyloid proteins.

Summary:

This review examines the diverse nature of amyloids, highlighting their structural conservation yet enigmatic formation processes.
It focuses on human amyloidoses, particularly their cutaneous manifestations, and stresses the importance of accurate diagnosis for effective management.
The paper synthesizes information on various amyloid classifications, diagnostic tools, and treatment options, including a discussion on functional versus pathogenic amyloids.

Impact:

Enhances understanding of amyloid diseases, aiding clinicians in diagnosis and treatment planning.
Provides a valuable resource for researchers investigating amyloidogenesis and related pathologies.
Contributes to differentiating beneficial amyloids from those causing significant human diseases.