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Updated: Jun 5, 2026

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC
Published on: January 30, 2018
Stromal mediation of radiation carcinogenesis
1Departments of Radiation Oncology and Cell Biology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA. MHBarcellos-Hoff@nyumc.org
Abstract:
Ionizing radiation is a well-established carcinogen in human breast and rodent mammary gland. This review addresses evidence that radiation elicits the critical stromal context for cancer, affecting not only frequency but the type of cancer. Recent data from the breast tumors of women treated with radiation therapy and the cellular mechanisms evident in experimental models suggest that radiation effects on stromal-epithelial interactions and tissue composition are a major determinant of cancer development.
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