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Updated: Jun 5, 2026

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
Published on: April 2, 2017
Role of nitric oxide in hepatic ischemia-reperfusion injury
Arunotai Siriussawakul1, Ahmed Zaky, John D Lang
1Department of Anesthesiology and Pain Medicine and the VA Puget Sound Healthcare System, the University of Washington School of Medicine, Seattle, WA 98108, United States.
Abstract:
Hepatic ischemia-reperfusion injury (IRI) occurs upon restoration of hepatic blood flow after a period of ischemia. Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress, cytokine release, leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI, role of inhaled NO in ameliorating IRI, modes of delivery, donor drugs and potential side effects of exogenous NO.

