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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Tissue-Drug Binding: Localization of Drugs and its Significance01:24

Tissue-Drug Binding: Localization of Drugs and its Significance

Body tissues, comprising approximately 40% of the body weight, are crucial in drug distribution and localization. These tissues can serve as drug storage sites, competing with plasma binding sites for drug molecules.
Drugs can bind to different tissue components, enhancing their distribution and localization. The factors influencing drug localization in tissues include the drug's lipophilicity, structural characteristics, tissue perfusion rate, and pH differences. These factors determine the...

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Related Experiment Video

Updated: Jun 5, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Cell-specific aptamer-mediated targeted drug delivery.

Jiehua Zhou1, John J Rossi

  • 1Division of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, USA.

Oligonucleotides
|December 25, 2010
PubMed
Summary

Nucleic acid aptamers are versatile tools for targeted drug delivery. This review highlights aptamer-based systems for enhanced therapeutic efficacy and clinical applications, focusing on cell membrane receptor targeting.

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Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
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Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery

Published on: June 23, 2011

Area of Science:

  • Biochemistry and Molecular Biology
  • Nanotechnology and Drug Delivery

Background:

  • Nucleic acid aptamers are single-stranded DNA or RNA oligonucleotides selected in vitro.
  • These aptamers possess unique 3D structures enabling specific target recognition.
  • Recent advancements focus on using aptamers as escort molecules to improve therapeutic agent efficacy.

Purpose of the Study:

  • To review recent developments in aptamer-mediated targeted delivery systems.
  • To emphasize aptamers evolved against cell membrane receptors.
  • To explore the potential for clinical translation of aptamer-based therapies.

Main Methods:

  • In vitro selection of nucleic acid aptamers.
  • Development of aptamer-mediated drug delivery systems.
  • Focus on aptamers targeting cell membrane receptors.

Main Results:

  • Aptamers can be engineered as effective drug delivery vehicles.
  • Cell-type-specific aptamers enhance targeted delivery of therapeutic agents.
  • Significant progress has been made in developing aptamer-based targeted therapies.

Conclusions:

  • Aptamer-mediated targeted delivery systems show great promise for clinical applications.
  • Further research into aptamers targeting cell membrane receptors is warranted.
  • Aptamers represent a valuable platform for next-generation therapeutics.