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Updated: Jun 5, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
The significance of anticardiolipin antibody and immunologic abnormality in livedoid vasculitis
Su-ying Feng1, Pei-ying Jin, Chang-geng Shao
1Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, China. fengsuying@medmail.com.cn
Objective:
To evaluate the significance of anticardiolipin and immunologic abnormality in the livedoid vasculitis (LV).
Methods:
30 patients with biopsy-proven LV and 30 normal controls involved in the study. Indirect immunofluorescence, immunoblot, and ELISA were used for detecting antinuclear antibody (ANA), circulating immune complex, immune globulin, anticardiophospholipin antibody (ACA), and anti-β(2) GP1.
Results:
ANA was positive in four patients with LV, and among them, two patients were diagnosed as Systemic Lupus Erythematosus (SLE) later. Addition to the two SLE patients, the level of ENA and immunoglobulin were normal in the rest of patients. Anticardiolipin antibodies were present in 13 (43.33%), and β(2) GP1 was present in nine (30%) of 30 patients. There were significant differences between LV and controls.
Conclusions:
ACA is one of important pathogenesis of LV. Numerous heterogeneous coagulation abnormalities and thrombogenesis may involve the LV.
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