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Updated: Jun 5, 2026
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
[Relationship between expression of VEGF-C and lymph node metastasis in human non-small cell lung cancer]
Zhendong Wang1, Ping Wang, Xinlong Chen
1Department of Cardiovascular and Thoracic Surgery, The First People's Hospital of Yunnan province, Kunming, Yunnan 650032, P.R.China.
Background:
It has been showed that VEGF-C can induce the proliferation of lymphocytes. The aim of this study is to explore the expression of VEGF-C in human non-small cell lung can-cer (NSCLC) and its relationship with lymph node metastasis.
Methods:
The expression of VEGF-C was examined in 60 human NSCLC tissues by immunohistochemical technique..
Results:
The positive rate of VEGF-C expression was 65.00% (39/60) in NSCLC tissues. The expression of VEGF-C was significantly higher in cases with lymph node metastasis (83.33%, 20/24) than in those without lymph node metastasis (52.78%, 19/36) (P < 0.05).
Conclusions:
There is an overexpression of VEGF-C protein in human NSCLC tissues, which may correlate with lymph node metastasis. The expression of VEGF-C protein might be used as a useful mar- ker of lymph node metastasis in NSCLC.
