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Published on: October 23, 2016
The structure and function of endophilin proteins
Ole Kjaerulff1, Lennart Brodin, Anita Jung
1Department of Neuroscience and Pharmacology, University of Copenhagen, 2200 Copenhagen, Denmark. okjaerulff@sund.ku.dk
Abstract:
Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They have a prominent function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes that require remodeling of the membrane structure. Here, we discuss the role of endophilins in these processes and summarize novel insights into the molecular aspects of endophilin function. Also, we discuss phosphorylation of endophilins and how this and other mechanisms may contribute to disease.
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