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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors
Johnny Y Nagasawa1, Jenny Song, Huanming Chen
1Department of Discovery Chemistry, Ardea Biosciences, Inc., 4939 Directors Place, San Diego, CA 92121, USA.
Bioorganic & Medicinal Chemistry Letters
|December 28, 2010
Abstract:
SAR studies on the quinolone carboxylic acid class of HIV-1 integrase inhibitors focused on improving the metabolic stability and led to the discovery of 27 and 38.
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