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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...

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Updated: Jun 5, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Mast cells and inflammation.

Theoharis C Theoharides1, Konstantinos-Dionysios Alysandratos, Asimenia Angelidou

  • 1Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA. theoharis.theoharides@tufts.edu

Biochimica Et Biophysica Acta
|December 28, 2010
PubMed
Summary
This summary is machine-generated.

Mast cells, crucial in immunity, also drive inflammatory diseases via non-allergic triggers. Understanding their selective mediator release offers new therapeutic targets for conditions like atopic dermatitis and psoriasis.

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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Related Experiment Videos

Last Updated: Jun 5, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Area of Science:

  • Immunology
  • Cell Biology
  • Inflammation Research

Background:

  • Mast cells are key players in allergic reactions and immunity.
  • Emerging evidence highlights their role in non-allergic inflammation, modulated by cytokines and neuropeptides.
  • Mast cells exhibit diverse responses, including selective mediator release without degranulation.

Purpose of the Study:

  • To explore the mechanisms regulating differential mast cell responses.
  • To understand how mast cells contribute to inflammatory diseases and immune modulation.
  • To identify potential therapeutic strategies targeting mast cell activity.

Main Methods:

  • Review of current literature on mast cell activation and mediator release.
  • Analysis of signaling pathways involved in mast cell degranulation and selective secretion.
  • Examination of the interplay between mast cells and T cells in inflammatory conditions.

Main Results:

  • Mast cells are activated by non-allergic triggers like IL-33 and neurotensin, often with synergistic effects.
  • Selective mediator release (e.g., IL-6, VEGF) occurs independently of degranulation.
  • Mast cell involvement in inflammatory diseases (atopic dermatitis, psoriasis, MS) is linked to stress and T cell cross-talk.

Conclusions:

  • Mitochondrial function may regulate mast cell degranulation but not selective release.
  • Understanding selective mast cell secretion is key to their diverse immunomodulatory roles.
  • Targeting selective mast cell secretion could lead to novel anti-inflammatory therapies.