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Updated: Jun 5, 2026
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
[MRP expression in non-small cell lung cancer and normal lung tissues and its prognostic significance]
Jun Hao1, Yan Wang, Qingchang Li
1Department of Pathology, College of Basic Medical Science, China Medical University, Shenyang, Liaoning 110001, P.R.China.
Background:
Drug-resistance of tumor is the main reason of the failure of che-motherapy. Much attention has been paid to the expression of multidrug resistance-associated protein (MRP) and its mechanism of drug-resistance in non-small cell lung cancer (NSCLC). Results of this research will contribute to reversing drug-resistance and improving curative effect. The aim of this study is to investigate the relationships between the expression of MRP and clinicopathological parameters and prognosis in patients with NSCLC.
Methods:
Expression of MRP was detected in 62 cases of paraffin-embedded NSCLC samples by streptavidin-biotin-peroxidase complex immunohistochemistry method, as well as in 30 fresh cases of NSCLC samples and corresponding normal lung tissues by immunohistochemistry and Western blot.
Results:
MRP expression of NSCLC tissues was significantly higher than that of normal lung tissues. The survival time of patients with negative MRP expression was (69.81±17.41) months, and that of patients with positive MPR expression was (25.38±4.46) months (P=0.0156). This statistically significant relationship between the survival time and prognosis was also showed in squamous cell carcinoma patients (P=0.015), but not in adenocarcinoma. Multivariate COX model analysis suggested that the survival time was significantly related to lymphatic metastasis (P=0.038) and expression of MRP (P=0.035).
Conclusions:
MRP expression in NSCLC is significantly higher than that in the normal lung tissues. The mean survival time of patients with negative MRP expression is remarkably longer than that of patients with positive MRP expression. MRP expression may be an independent prognostic factor.
Insights
Multidrug resistance-associated protein (MRP) is highly expressed in non-small cell lung cancer (NSCLC) tissues. Higher MRP expression correlates with shorter survival times, indicating its potential as a prognostic factor.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Context:
- Tumor drug resistance is a primary cause of chemotherapy failure.
- Multidrug resistance-associated protein (MRP) expression and its role in drug resistance are critical in non-small cell lung cancer (NSCLC).
- Understanding MRP's role can help overcome drug resistance and improve treatment outcomes.
Purpose:
- To investigate the relationship between MRP expression and clinicopathological parameters in NSCLC patients.
- To assess the correlation between MRP expression and patient prognosis in NSCLC.
Summary:
- MRP expression was significantly elevated in NSCLC tissues compared to normal lung tissues.
- Patients with negative MRP expression had a mean survival of 69.81 months, versus 25.38 months for those with positive MRP expression (P=0.0156).
- Multivariate analysis identified MRP expression and lymphatic metastasis as significant prognostic factors.
Impact:
- MRP expression is significantly higher in NSCLC than in normal tissues.
- Negative MRP expression is associated with significantly longer survival.
- MRP expression may serve as an independent prognostic marker for NSCLC patients.
