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Updated: Jun 5, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Genetic polymorphisms in periodontal diseases: an overview
R Vijayalakshmi1, A Geetha, T Ramakrishnan
1Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, India. srvijayalakshmi@rediffmail.com
Summary
Genetics plays a role in periodontitis susceptibility. This review explores how genetic polymorphisms influence the development and progression of periodontal diseases, highlighting key genetic factors.
Area of Science:
- Oral biology
- Genetics
- Periodontology
Background:
- Periodontitis is a complex oral disease influenced by multiple factors.
- Genetic predisposition is recognized as a significant susceptibility factor in periodontitis.
- Understanding genetic influences is crucial for personalized risk assessment.
Purpose of the Study:
- To review the current literature on the role of genetic polymorphisms in periodontal diseases.
- To highlight specific genetic variations associated with periodontitis susceptibility and severity.
- To synthesize information on the genetic basis of periodontitis for researchers and clinicians.
Main Methods:
- Nonsystematic literature review.
- Focused search on genetic polymorphisms and periodontal diseases.
- Synthesis of findings from selected studies.
Main Results:
- Several genetic polymorphisms have been associated with increased risk or altered progression of periodontitis.
- Specific genes involved in immune response and inflammation show significant associations.
- The impact of genetic factors varies across different populations.
Conclusions:
- Genetic polymorphisms are important determinants of individual susceptibility to periodontitis.
- Further research into gene-environment interactions is needed.
- Genetic insights can potentially lead to novel diagnostic and therapeutic strategies for periodontal diseases.
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