Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Frame-wise multi-echo distortion correction for superior functional MRI.

Imaging neuroscience (Cambridge, Mass.)·2026

Same author

Predictive acoustical processing in human cortical layers.

Nature communications·2026

Same author

An 80-channel receive array for 10.5T neuroimaging: Key considerations for SNR optimization.

bioRxiv : the preprint server for biology·2026

Same author

Functional MRI of the Human Hippocampus at 10.5T: Pushing the Boundaries of Spatial Resolution.

bioRxiv : the preprint server for biology·2026

Same author

Cubic Millimeter High Resolution 3D Inner-Volume GRASE (IV-GRASE) CEST MRI Using T<sub>1</sub>-Integrated Variable Density CAIPI Sampling With Temporal Random Walk: A Feasibility Study.

Magnetic resonance in medicine·2026

Same author

Bridging the gap with invasive imaging: promises and challenges of a new generation of ultrahigh resolution fMRI.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Multiplexed echo planar imaging for sub-second whole brain FMRI and fast diffusion imaging.

David A Feinberg¹, Steen Moeller, Stephen M Smith

¹Advanced MRI Technologies, Sebastopol, California, United States of America. david.feinberg@advancedmri.com

|December 29, 2010

Summary

This summary is machine-generated.

Multiplexed-EPI (M-EPI) significantly reduces scan times for functional MRI (fMRI) and diffusion imaging. This advanced technique enhances temporal resolution and functional sensitivity without compromising spatial resolution.

More Related Videos

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Published on: August 19, 2010

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Related Experiment Videos

Last Updated: Jun 5, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Published on: August 19, 2010

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Area of Science:

Neuroimaging
Magnetic Resonance Imaging (MRI)
Neuroscience

Background:

Echo planar imaging (EPI) is crucial for functional MRI (fMRI) and diffusion imaging in neuroscience.
Current EPI techniques require lengthy scan times for whole-brain coverage, limiting temporal resolution.
Acquiring multi-slice whole-brain data for fMRI and diffusion imaging typically takes seconds.

Purpose of the Study:

To report a significant reduction in EPI whole-brain scan time at 3 and 7 Tesla.
To introduce the novel multiplexed-EPI (M-EPI) pulse sequence.
To demonstrate improved functional sensitivity and preserved spatial resolution.

Main Methods:

Developed the multiplexed-EPI (M-EPI) pulse sequence combining temporal (simultaneous echo refocused - SIR) and spatial (multibanded RF pulses - MB) multiplexing.
Applied M-EPI for whole-brain fMRI at 3 Tesla, achieving repetition times (TRs) of 400 ms and 800 ms.
Utilized M-EPI for high angular resolution diffusion imaging (HARDI) of neuronal fiber tracts, achieving 2-4 times scan time reduction.
Evaluated M-EPI performance at 7 Tesla, noting reduced specific absorption rate (SAR) due to fewer RF pulses and elimination of fat suppression.

Main Results:

Achieved unprecedented reduction in EPI scan time for whole-brain fMRI at 3 Tesla (TRs of 400 ms and 800 ms vs. conventional 2.5 sec).
Reduced scan times by 2-4 times for HARDI imaging of neuronal fiber tracts.
Observed a 6-fold higher sampling rate in resting-state fMRI studies, leading to a 60% increase in peak functional sensitivity.
Demonstrated reduced SAR at 7 Tesla by optimizing RF refocusing and shifting fat signal.

Conclusions:

The novel M-EPI pulse sequence significantly increases temporal resolution for whole-brain fMRI.
M-EPI enables studying non-stationarity in brain networks and enriches functional information.
This methodology offers a valuable advancement for neuroimaging research, improving efficiency and data quality.