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Related Concept Videos

Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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Updated: May 9, 2026

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
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Cubic Millimeter High Resolution 3D Inner-Volume GRASE (IV-GRASE) CEST MRI Using T1-Integrated Variable Density CAIPI

Hahnsung Kim1,2, Suhyung Park3, Julius Juhyun Chung1

  • 1Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA.

Magnetic Resonance in Medicine
|May 8, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a novel hybrid T1-CEST MRI sequence for efficient, high-resolution imaging. The advanced technique enhances quantitative stability and reduces artifacts, improving diagnostic capabilities.

Keywords:
3Dchemical exchange saturation transfer (CEST)gradient and spin echo (GRASE)random‐walk sampling

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Quantitative Imaging

Background:

  • Chemical Exchange Saturation Transfer (CEST) MRI offers valuable insights into tissue physiology.
  • Current CEST MRI techniques often face challenges with efficiency, resolution, and quantitative accuracy.
  • Simultaneous acquisition of T1-weighted and CEST data is desirable for comprehensive tissue characterization.

Purpose of the Study:

  • To develop a novel cubic-millimeter, high-resolution Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) sequence.
  • To enhance the efficiency and quantitative stability of CEST MRI.
  • To enable simultaneous T1-weighted and CEST imaging in a single acquisition.

Main Methods:

  • Developed a hybrid sequence combining inversion-recovery T1 and multi-offset CEST modules using inner-volume GRASE (IV-GRASE) readout.
  • Improved acquisition efficiency with variable-density random-walk sampling.
  • Employed a self-calibrated joint reconstruction framework with sparsity and low-rank constraints.

Main Results:

  • Achieved simultaneous T1 and CEST imaging with reduced artifacts and improved quantitative stability.
  • Demonstrated accurate T1 and Z-spectral measurements in phantoms with co-registered datasets.
  • Preliminary patient studies revealed distinct tissue heterogeneity and exchange-dependent relaxation contrast.

Conclusions:

  • The proposed hybrid T1-CEST MRI sequence offers efficient, artifact-reduced, and quantitatively reliable high-resolution imaging.
  • This advancement facilitates the feasibility of quantitative CEST analysis in clinical settings.
  • The sequence enables comprehensive tissue characterization in a single MRI acquisition.