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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Published on: December 9, 2015

Vitamin d and multiple sclerosis: correlation, causality, and controversy.

Joost Smolders1

  • 1Division of Clinical and Experimental Immunology, Department of Internal Medicine and School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

Autoimmune Diseases
|December 29, 2010
PubMed
Summary

Recent studies link vitamin D levels to multiple sclerosis (MS) activity. This review examines vitamin D status, disability scores, and relapses in MS patients, offering insights for future supplementation trials.

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Area of Science:

  • Neurology
  • Endocrinology
  • Immunology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease with complex etiology.
  • Vitamin D, a crucial hormone, has been investigated for its potential role in immune modulation and neuroprotection.
  • Emerging evidence suggests a correlation between vitamin D status and MS disease activity.

Purpose of the Study:

  • To review existing literature on the association between vitamin D status and multiple sclerosis (MS) disease activity.
  • To analyze the relationship between vitamin D levels, Expanded Disability Status Scale (EDSS) scores, and MS relapse rates.
  • To provide recommendations for future vitamin D supplementation intervention studies in MS patients.

Main Methods:

  • Systematic literature review of studies investigating vitamin D and MS.
  • Analysis of data correlating vitamin D levels with clinical MS parameters.
  • Synthesis of findings regarding EDSS scores and relapse activity in relation to vitamin D status.

Main Results:

  • Multiple studies report associations between vitamin D correlates and MS disease activity markers.
  • Evidence suggests a link between lower vitamin D status and increased MS relapse rates and disability progression (EDSS).
  • The review consolidates findings on the interplay between vitamin D and MS pathogenesis.

Conclusions:

  • Vitamin D status is a relevant factor associated with multiple sclerosis disease activity.
  • Further research, including well-designed intervention studies, is warranted to establish causality and optimal supplementation strategies for MS.
  • Understanding the role of vitamin D may inform future therapeutic approaches for multiple sclerosis.