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Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...
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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
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Tools for assessing nausea, vomiting, and retching.

Janelle M Wood1, Kathleen Chapman, June Eilers

  • 1The Nebraska Medical Center, Omaha, USA. jwood@nebraskamed.com

Cancer Nursing
|December 29, 2010
PubMed
Summary

This review identifies 25 instruments for assessing chemotherapy-induced nausea, vomiting, and retching in cancer patients. While no single tool is perfect, the findings help clinicians select the best option for patient care.

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Area of Science:

  • Oncology
  • Patient Care

Background:

  • Chemotherapy-induced nausea, vomiting, and retching significantly impact patient well-being, quality of life, and treatment choices.
  • Existing assessment tools often lack completeness or conciseness for clinical use.

Purpose of the Study:

  • To comprehensively review instruments for assessing cancer-related nausea, vomiting, and retching.
  • To analyze the symptoms measured, evaluation periods, question types, and specific aspects of each symptom.

Main Methods:

  • Conducted literature searches using national oncology websites and databases (PubMed, MEDLINE/CINAHL, Cochrane).

Main Results:

  • Identified 25 instruments suitable for adult oncology patients.
  • Evaluated instruments based on measured symptoms, timeframes, question design, and symptom aspects.

Conclusions:

  • The ideal instrument measures all three symptoms (nausea, vomiting, retching) while being clear, concise, and clinically relevant.
  • One instrument closely met these criteria; this review aids nurses in selecting appropriate tools for clinical settings to optimize patient care.