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Updated: Jun 5, 2026
Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct
Published on: January 22, 2010
Preventative effect of various fluids used in the epitympanic bulla on deterioration of cochlear function during
Ryoukichi Ikeda1, Kazuhiro Nakaya, Takeshi Oshima
1Department of Otolaryngology-Head & Neck Surgery, Tohoku University School of Medicine, Sendai, Japan. ryoukich@hotmail.com
Conclusion:
Preventing leakage of endolymph during vestibular destruction may be important in the acute phase.
Objectives:
Vestibulotomy causes significant decrease in the endocochlear potential (EP). The effect of artificial perilymph and distilled water administration during vestibulotomy on hearing preservation was evaluated in Hartley guinea pigs.
Methods:
Animals were divided into three groups: the epitympanic bulla was filled with artificial perilymph or distilled water, or was not filled with any solution (control group). The EP and [K(+)] were monitored using double-barrelled ion-selective microelectrodes in the second turn of the cochlea.
Results:
EP was not significantly different between the artificial perilymph and the distilled water groups, although both groups showed better preservation of EP compared with the control group. The [K(+)] was not significantly different between the three groups.
