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Updated: Jun 5, 2026
Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
Published on: March 15, 2019
[Effects of acute hypoxia on plasma metabolome in mice]
Yu-ping Wang1, Chang-jiang Guo, Ji-jun Yang
1Institute of Health and Environmental Medicine, Academy of Military Medieal Sciences, Tianjin 300050, China.
Aim:
To explore the metabolic effects of acute hypoxia on mice plasma.
Methods:
Fourteen mice were randomly divided into two groups: control and hypoxia group. The mice of hypoxia group were exposed to a simulated altitude of 6000 meters for 8 hours. Nuclear magnetic resonance spectrometer was used to identify the metabolic changes after acute hypoxia.
Results:
Compared with control, the most notable significantly after acute hypoxia exposure. remarkably and lactate increased metabolic changes in plasma were as follows: camrnitine decreased levels of lipids and pyruvate, alanine, taurine, Decreases in levels of beta-HB, ethanol glycerol, glutamate, glycine and serine, and increased choline, glucose, and glutamine were also observed in hypoxia group.
Conclusion:
Significant changes in the plasma carbohydrate, lipid and amino acid profiles were observed following acute hypoxia, suggesting a hypoxia-induced alteration in energy and related substances metabolism.
