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[The autonomic nervous system involved in regulation of immune function in rats during hypoxia]
1Department of Biological Science and Medical Engineering, Zhejiang University, Hangzhou 310027, China.
Aim:
To study of autonomic nervous system modulation of lymphocyte proliferation during hypoxia.
Methods:
Rats were exposed to 5 km and 7 km altitude in a hypobaric chamber for 24 h or 48 h, the effect of autonomic nervous system on mitogen-induced spleen lymphocyte response to the acute hypoxia was investigated.
Results:
When rats were exposed to 5 km altitude for 24 h, which inhibited spleen T lymphocyte proliferation induced by concanavalin (Con A), but the action was abolished through peripheral sympathetic-destroyed. When mouse were exposed anoxia environment at 0.07 MPa for 10 min, the norepinephrine and epinephrine in plasma were increased markedly. T cells of rats were in vitro incubated simultaneously with ACh showing a concentration dependent enhancement of T cell proliferation. The plasma levels of ACh were decreased after rats were exposed to 5 km for 24 h.
Conclusion:
Autonomic nervous system was involved in the regulation of immune function in rats during hypoxia.
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