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Updated: Jun 5, 2026

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
Published on: December 9, 2021
[Effects of several different irritation factors on leukocytes adhesion in microvessels]
Aim:
The interrelation of adhesion between leukocyte and endothelium was studied by several irritation factors.
Methods:
Leukocyte adhesion was observed by impulse electricity irritation, ischemia/reperfusion, endotoxin and IL-8 in venular of rat mesentery.
Results:
The results showed these irritation factors resulted in a significant increase in the number of leukocytes adhesion along the venular endothelium of rat mesentery. IL-8 leaded to the most increase of leukocytes adhesion. Especially treated by IL-8 for 30 minutes. The number of leukocytes adhesion of the others was approximately identical.
Conclusion:
The study suggests that impulse electricity irritation, ischemia/reperfusion, endotoxin and IL-8 are able to induce leukocytes and endothelium adhesion, and IL-8 of them has the most effect.
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