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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: Jun 5, 2026

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells
10:49

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

Published on: April 14, 2013

Disease-specific pluripotent stem cells.

Hoon-Chul Kang1

  • 1Department of Pediatrics, Pediatric Epilepsy Clinics, Severance Children's Hospital, Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Korean Journal of Pediatrics
|December 31, 2010
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem (iPS) cells offer a revolutionary approach to regenerative medicine. These reprogrammed cells hold immense potential for disease modeling, drug discovery, and cell replacement therapies.

Keywords:
Induced pluripotent stem cellsTranscription factors

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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

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Last Updated: Jun 5, 2026

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells
10:49

The Specification of Telencephalic Glutamatergic Neurons from Human Pluripotent Stem Cells

Published on: April 14, 2013

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
08:00

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

Area of Science:

  • Biotechnology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Somatic cells can be epigenetically reprogrammed into induced pluripotent stem (iPS) cells via exogenous transcription factor expression.
  • iPS cells possess self-renewal capacity and pluripotency, enabling differentiation into diverse cell types.
  • Generating iPS cells from patients with genetic diseases is crucial for advancing personalized medicine.

Purpose of the Study:

  • To review the current advancements in iPS cell technology.
  • To explore the applications of iPS cells in disease modeling and drug discovery.
  • To discuss the future potential of iPS cells in cell replacement therapy.

Main Methods:

  • Epigenetic reprogramming of somatic cells.
  • Exogenous expression of specific transcription factors.
  • Culturing and differentiation of iPS cells.

Main Results:

  • iPS cell technology has progressed significantly, enabling disease-specific cell generation.
  • iPS cells provide valuable platforms for investigating genetic disorders in vitro.
  • The potential for therapeutic applications is substantial, though further research is needed.

Conclusions:

  • iPS cells represent a transformative technology in regenerative medicine.
  • Their application in disease modeling and drug discovery is already impactful.
  • Cell replacement therapy using iPS cells holds future promise for treating various conditions.