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Induction of the proto-oncogene c-jun by angiotensin II
A J Naftilan1, G K Gilliland, C S Eldridge
1Hypertension Program, University of Alabama, Birmingham 35294.
Molecular and Cellular Biology
|October 1, 1990
Abstract:
Angiotensin (Ang) II causes hypertrophy of rat aortic smooth muscle cells in culture and results in the rapid activation of c-fos. This study demonstrated that Ang II also activated c-jun and, in addition, could activate the AP-1 enhancer element. These data add support for a role of Ang II as an important mediator of vascular smooth muscle cell growth.