Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Colloidal precipitates01:09

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A case report of spherical pneumonia caused by <i>Chlamydia psittaci</i> infection.

Frontiers in medicine·2026
Same author

Machine-Learning Microfluidic Minute-Scale Microorganism Metrics Monitoring(M6).

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Hierarchical Oil-Water-Oil Pickering Double Emulsions Stabilized by Tubular Nanoparticles.

Journal of the American Chemical Society·2026
Same author

Long-Tea-CLIP: An Expert-Level Multimodal AI Framework for Fine-Grained Green Tea Grading Across Five Sensory Dimensions.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Artificial intelligence-powered nanomedicine.

Chemical Society reviews·2026
Same author

Correction to "Halloysite/polyaniline Nanocomposites for Enhanced Actinide Sorption".

ACS applied materials & interfaces·2026

Related Experiment Video

Updated: Jun 5, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Converting poorly soluble materials into stable aqueous nanocolloids.

Yuri M Lvov1, Pravin Pattekari, Xingcai Zhang

  • 1Institute for Micromanufacturing, Louisiana Tech University, Ruston, Louisianna, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|December 31, 2010
PubMed
Summary

Researchers created stable, water-dispersible nanoparticles from poorly soluble materials using ultrasonicated layer-by-layer encapsulation. This method enhances the utility of compounds like drugs and anticorrosion agents by improving their colloidal stability.

More Related Videos

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Area of Science:

  • Materials Science
  • Colloid Chemistry
  • Nanotechnology

Background:

  • Poorly soluble materials present challenges in aqueous formulations.
  • Traditional methods often struggle to achieve stable dispersions of such materials.

Purpose of the Study:

  • To develop a novel method for producing stable aqueous nanocolloids of poorly soluble substances.
  • To enhance the water dispersibility and colloidal stability of various low-solubility materials.

Main Methods:

  • Utilized a sonicated layer-by-layer (LbL) encapsulation technique.
  • Employed polycation/polyanion shells for nanoparticle coating.
  • Simultaneously broke powder particles and coated them using ultrasonication.

Main Results:

  • Successfully produced polyelectrolyte-coated nanoparticles with diameters of 150-200 nm.
  • Achieved sufficient surface electrical potential for excellent colloidal stability.
  • Demonstrated increased water dispersibility for a range of materials.

Conclusions:

  • Sonicated LbL encapsulation is an effective method for creating stable nanocolloids from poorly soluble materials.
  • The technique significantly improves the aqueous dispersibility of diverse compounds, including drugs, anticorrosion agents, dyes, and salts.
  • This approach offers a versatile platform for enhancing the application of low-solubility substances.