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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Asthma-II: Pathophysiology and Classification01:26

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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Immunoglobulin-like Cell Adhesion Molecules

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Updated: Jun 5, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Mast cell activation and autism.

Theoharis C Theoharides1, Asimenia Angelidou, Konstantinos-Dionysios Alysandratos

  • 1Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA. theoharis.theoharides@tufts.edu

Biochimica Et Biophysica Acta
|January 4, 2011
PubMed
Summary
This summary is machine-generated.

Mast cell activation, not typical allergies, may contribute to autism spectrum disorder (ASD) pathogenesis. Perinatal inflammation and mast cell mediators could play a role in neurodevelopmental outcomes and ASD risk.

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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Published on: May 27, 2015

Area of Science:

  • Neuroimmunology
  • Developmental Neuroscience
  • Allergy and Inflammation

Background:

  • Autism spectrum disorder (ASD) prevalence is rising, yet its pathogenesis remains unclear.
  • Evidence suggests increased pro-inflammatory cytokines and antibodies against brain proteins in ASD.
  • Children with ASD may exhibit "allergic-like" symptoms without typical allergy markers, suggesting non-allergic mast cell activation.

Purpose of the Study:

  • To explore the potential role of non-allergic mast cell activation in autism spectrum disorder pathogenesis.
  • To investigate the link between perinatal inflammation, mast cell activation, and neurodevelopmental outcomes.

Main Methods:

  • Review of existing literature on ASD, inflammation, mast cell activation, and neurodevelopment.
  • Analysis of parental reports on "allergic-like" symptoms in children with ASD.
  • Consideration of the impact of in utero and perinatal inflammation on brain development.

Main Results:

  • Non-allergic mast cell activation, triggered by various factors, may release inflammatory and neurotoxic molecules.
  • In utero and perinatal inflammation are associated with adverse neurodevelopmental outcomes, including increased ASD risk.
  • Premature infants exhibit higher ASD risk and are more susceptible to infections and neurotoxins due to immature barriers.

Conclusions:

  • Perinatal mast cell activation could contribute to brain inflammation and ASD pathogenesis in a subset of patients.
  • Understanding mast cell involvement may offer new avenues for ASD early detection and treatment strategies.
  • Further research is warranted to elucidate the precise mechanisms linking mast cells, inflammation, and ASD.