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Does left ventricular diastolic function deteriorate earlier than left ventricular systolic function in anthracycline

Chetan D Patel1, Vijay Babu Balakrishnan, Lalit Kumar

  • 1Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi-110029, India. chetantruptipatel@hotmail.com

Hellenic Journal of Nuclear Medicine
|January 4, 2011
PubMed

Insights

Anthracycline chemotherapy can cause cardiotoxicity. This study found that left ventricular diastolic function (LVDF) declines before left ventricular systolic function (LVSF) in patients undergoing this treatment.

Area of Science:

  • Cardiology
  • Oncology
  • Pharmacology

Background:

  • Cardiotoxicity is a significant complication of anthracycline chemotherapy.
  • Early detection of cardiac dysfunction is crucial for patient management.

Purpose of the Study:

  • To investigate whether left ventricular diastolic function (LVDF) deteriorates earlier than left ventricular systolic function (LVSF) in patients receiving anthracyclines.
  • To assess changes in cardiac function during anthracycline treatment.

Main Methods:

  • Prospective study of 58 patients undergoing anthracycline chemotherapy.
  • Evaluation of left ventricular systolic function (LVSF) using left ventricular ejection fraction (LVEF) and peak ejection rate (PER) via equilibrium radionuclide angiography (ERNA).
  • Assessment of left ventricular diastolic function (LVDF) using peak filling rate (PFR) and other diastolic parameters from ERNA.

Main Results:

  • A significant decrease in LVEF and PER was observed between cumulative doses of 139 mg/m² (S1) and 308 mg/m² (S2).
  • A significant decrease in PFR was noted between baseline (S0) and 139 mg/m² (S1).
  • These findings indicate an earlier decline in diastolic function compared to systolic function.

Conclusions:

  • Left ventricular diastolic function (LVDF) deteriorates earlier than left ventricular systolic function (LVSF) in patients treated with anthracyclines.
  • Monitoring LVDF may allow for earlier detection of cardiotoxicity during anthracycline chemotherapy.

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