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Oral nimodipine inhibits the ovarian cycle in mice
Ofer Fainaru1, Ross Firestone, Robert F Casper
1Toronto Centre for Advanced Reproductive Technology, Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
Fertility and Sterility
|January 4, 2011
Abstract:
Nimodipine, a calcium-channel blocker that can cross the blood-brain barrier, has been shown to inhibit pulsatile GnRH release in vitro. We now show that oral nimodipine can effectively inhibit the ovarian cycle in mice in a dose-related manner.
