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Published on: July 1, 2013
A three-year evaluation of hemostatic function in Singaporean Norplant-2 rod acceptors
K Singh1, O A Viegas, S S Ratnam
1Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital.
Insights
Norplant-2 contraceptive use for three years may increase thrombosis risk. This is shown by higher platelet counts, aggregability, and altered coagulation times, suggesting hypercoagulation potential.
Area of Science:
- Reproductive Health
- Hematology
- Pharmacology
Background:
- Long-term use of hormonal contraceptives requires ongoing safety evaluation.
- Understanding hemostatic changes associated with contraceptive implants is crucial for risk assessment.
Purpose of the Study:
- To assess the longitudinal effects of Norplant-2 rods on hemostatic function over three years.
- To investigate potential alterations in coagulation parameters indicative of thrombosis risk.
Main Methods:
- A three-year longitudinal study involving 100 Singaporean Norplant-2 acceptors.
- Monitoring of platelet count, platelet aggregability, prothrombin time (PT), activated partial thromboplastin time (APTT), and vitamin K coagulation factors.
Main Results:
- Significant increases in platelet count and aggregability observed.
- Prothrombin time (PT) and activated partial thromboplastin time (APTT) remained shortened throughout the study.
- A general decrease in most vitamin K-dependent coagulation factors was noted.
Conclusions:
- Three years of Norplant-2 use may be associated with an increased predisposition to thrombosis.
- Findings suggest a potential for enhanced hypercoagulation in long-term Norplant-2 users.
Abstract:
A longitudinal study of hemostatic function was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraception. The results at the end of three years indicate a possible increased predisposition to thrombosis, as evidenced by significant increases in platelet count and aggregability. The prothrombin time (PT) and activated partial thromboplastin time (APTT) continued to remain shortened at the end of three years of use. There was also a general fall in most of the vitamin K coagulation factors. There is thus still an indication of a possible enhanced potential for hypercoagulation at the end of three years of Norplant-2 rod use.
