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Related Experiment Video

Updated: Jun 5, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

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L2pB1: a new player in autoimmunity.

Xuemei Zhong¹, Thomas L Rothstein

¹Hematology and Oncology Section, Department of Medicine, Boston University Medical Center, Boston, MA, USA. xuemei.zhong03@gmail.com

Molecular Immunology

|January 4, 2011

Summary

Newly discovered PD-L2-positive B1 (L2pB1) cells exhibit self-reactive B cell receptor repertoires and promote autoimmunity. These L2pB1 cells are implicated in lupus pathogenesis, suggesting a role in autoimmune diseases.

Area of Science:

Immunology
Autoimmunity
Cell Biology

Background:

A novel subpopulation of B1 B cells, termed PD-L2-positive B1 (L2pB1) cells, has been identified.
L2pB1 cells express PD-L2 (CD273, B7-DC), a ligand for the inhibitory receptor PD-1, distinguishing them from PD-L2-negative B1 (L2nB1) cells.

Purpose of the Study:

To review the unique characteristics of L2pB1 cells.
To explore the potential role of L2pB1 cells in the pathophysiology of autoimmune diseases.

Main Methods:

Comparative analysis of L2pB1 and L2nB1 cell features.
Examination of L2pB1 cell numbers and autoantibody titers in murine lupus models.

Main Results:

L2pB1 cells share common B1 cell traits but possess a biased Ig repertoire enriched for self-reactivity.

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L2pB1 cells exhibit enhanced antigen presentation and isotype switching capabilities (IgM to IgG1/IgG2b).

Increased L2pB1 cell populations correlate with higher anti-dsDNA titers in lupus models.

Conclusions:

L2pB1 cells display distinct features, including self-reactivity and potent antigen presentation, suggesting a role in autoimmunity.
The increased presence of L2pB1 cells in lupus models highlights their potential pathophysiological contribution to autoimmune dyscrasias.